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  1. ; ; ; ( , The Journal of Physiology)
    Abstract

    The control of calcium influx at the plasma membrane by endoplasmic reticulum (ER) calcium stores, a process common to invertebrates and vertebrates, is central to physiological calcium signalling and cellular calcium balance. Stromal interaction molecule 1 (STIM1) is a calcium sensor and regulatory protein localized to the ER. ORAI1 is a calcium channel in the plasma membrane (PM). In outline, STIM1 senses an ER‐luminal calcium decrease, relocalizes to ER–PM junctions, and recruits and gates ORAI1 channels. Recent work, reviewed here, has offered detailed insight into the process of sensing and communicating ER calcium‐store depletion, and particularly into the STIM1 conformational change that is the basis for communication between the ER and the PM.image

     
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  2. ; ; ; ; ; ; ; ; ; ; et al ( , Frontiers in Marine Science)
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